Vincent Giguère Selected Research

ERRalpha Estrogen-Related Receptor

1/2021	Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis.
12/2010	Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis.
1/2010	Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathway.
11/2009	Absence of ERRalpha in female mice confers resistance to bone loss induced by age or estrogen-deficiency.
8/2009	Genome-wide identification of direct target genes implicates estrogen-related receptor alpha as a determinant of breast cancer heterogeneity.
7/2007	The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload.
11/2006	Estrogen related receptor-alpha enhances surfactant protein-A gene expression in fetal lung type II cells.
7/2005	Epidermal growth factor-induced signaling in breast cancer cells results in selective target gene activation by orphan nuclear receptor estrogen-related receptor alpha.
12/2004	Estrogen-related receptor alpha (ERRalpha) is a transcriptional regulator of apolipoprotein A-IV and controls lipid handling in the intestine.
11/2003	Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha.

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Vincent Giguère Research Topics

Disease

24	Neoplasms (Cancer) 12/2022 - 09/2006
22	Breast Neoplasms (Breast Cancer) 12/2022 - 07/2002
12	Prostatic Neoplasms (Prostate Cancer) 02/2024 - 03/2012
5	Neoplasm Metastasis (Metastasis) 01/2020 - 08/2011
4	Inflammation (Inflammations) 10/2021 - 11/2005
4	Carcinogenesis 01/2019 - 12/2010
3	Insulin Resistance 01/2022 - 02/2008
3	Non-alcoholic Fatty Liver Disease 10/2021 - 04/2013
2	Metabolic Diseases (Metabolic Disease) 03/2024 - 08/2011
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 01/2019
2	Body Weight (Weight, Body) 01/2018 - 11/2003
2	Osteoporosis 06/2017 - 11/2009
2	Cardiomegaly (Heart Hypertrophy) 02/2008 - 07/2007
2	Heart Failure 07/2007 - 07/2007
1	Cardiotoxicity 12/2022
1	Hypoxia (Hypoxemia) 01/2022
1	Hemolysis 01/2022
1	Anemia 01/2022
1	Liver Diseases (Liver Disease) 10/2021
1	Alcoholic Fatty Liver 10/2021
1	Fibrosis (Cirrhosis) 10/2021
1	Liver Cirrhosis (Hepatic Cirrhosis) 10/2021
1	Colitis 01/2021
1	Triple Negative Breast Neoplasms 10/2020
1	Hematologic Neoplasms (Hematological Malignancy) 10/2020
1	Septic Shock (Toxic Shock Syndrome) 07/2015
1	Genetic Predisposition to Disease (Genetic Predisposition) 02/2014
1	Hepatocellular Carcinoma (Hepatoma) 10/2013
1	Hyperlipidemias (Hyperlipidemia) 04/2013
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 08/2011

Drug/Important Bio-Agent (IBA)

10	ERRalpha Estrogen-Related ReceptorIBA 01/2021 - 11/2003
9	Estrogens (Estrogen)FDA Link 03/2024 - 07/2002
8	AndrogensIBA 02/2024 - 03/2012
6	Transcription Factors (Transcription Factor)IBA 10/2023 - 09/2006
6	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2022 - 06/2005
6	Estrogen Receptor alphaIBA 08/2009 - 07/2002
5	Orphan Nuclear ReceptorsIBA 01/2018 - 07/2005
4	ChromatinIBA 01/2022 - 06/2005
4	DNA (Deoxyribonucleic Acid)IBA 10/2020 - 07/2005
4	Hormones (Hormone)IBA 01/2020 - 09/2006
4	Androgen Receptors (Androgen Receptor)IBA 01/2017 - 03/2012
3	EnzymesIBA 01/2022 - 12/2013
3	LipidsIBA 10/2021 - 01/2017
3	Triglycerides (Triacylglycerol)IBA 10/2021 - 01/2018
3	Estrogen ReceptorsIBA 04/2014 - 06/2005
3	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 01/2014 - 06/2005
2	Phosphotransferases (Kinase)IBA 02/2024 - 10/2023
2	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2022 - 01/2021
2	Insulin (Novolin)FDA Link 01/2022 - 02/2008
2	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2019
2	MethyltransferasesIBA 10/2020 - 01/2018
2	RetinoidsIBA 01/2014 - 01/2011
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2006 - 07/2005
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 02/2024
1	Amino Acids FDA Link 01/2022
1	IsomerasesIBA 01/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2022
1	Methionine (L-Methionine)FDA Link 10/2021
1	Choline (Choline Chloride)IBA 10/2021
1	Epirubicin (Ellence)FDA LinkGeneric 01/2021
1	BiguanidesIBA 01/2021
1	Glutathione (Reduced Glutathione)IBA 01/2021
1	Phenformin (Fenformin)IBA 01/2021
1	AnthracyclinesIBA 01/2021
1	Buthionine SulfoximineIBA 01/2021
1	GSK5182IBA 01/2020
1	AntioxidantsIBA 01/2020
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2020
1	Histone MethyltransferasesIBA 01/2019
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2019
1	fibroblast growth factor 21IBA 01/2019
1	CSK Tyrosine-Protein KinaseIBA 01/2019
1	Citric Acid (Citrate)FDA LinkGeneric 01/2018
1	Phenobarbital (Luminal)FDA Link 01/2018
1	Histones (Histone)IBA 01/2018
1	Tyrosine Kinase InhibitorsIBA 12/2016
1	Lapatinib (GW572016)FDA Link 12/2016
1	Folic Acid (Vitamin M)FDA LinkGeneric 02/2016
1	Methotrexate (Mexate)FDA LinkGeneric 02/2016
1	CarbonIBA 02/2016
1	AMP-Activated Protein KinasesIBA 01/2016
1	Toll-Like Receptors (Toll-Like Receptor)IBA 07/2015
1	EndotoxinsIBA 07/2015
1	Monoclonal AntibodiesIBA 12/2014
1	Trastuzumab (Herceptin)FDA Link 12/2014
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2014
1	Glutamine (L-Glutamine)FDA Link 12/2013
1	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 10/2013
1	CarcinogensIBA 10/2013
1	CateninsIBA 07/2013
1	Sirolimus (Rapamycin)FDA Link 04/2013
1	Oncogene Proteins (Oncogene Protein)IBA 01/2013
1	Protein Tyrosine PhosphatasesIBA 03/2012
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 03/2012
1	Protein Isoforms (Isoforms)IBA 08/2011

Therapy/Procedure

8	Therapeutics 12/2022 - 01/2013
2	Castration 01/2017 - 01/2017
1	Prostatectomy (Retropubic Prostatectomy) 01/2022
1	Drug Therapy (Chemotherapy) 01/2021
1	Ovariectomy (Oophorectomy) 06/2017